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Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41... By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-...
www.nature.com
Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours - Nature Biomedical Engineering
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Jan Böttcher