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by @jimpick.com
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I hope that Nullstrap-DE can be a useful add-on to calibrate the FDR control of popular parametric DE methods, including DESeq2 and edgeR, while maintaining the strong power. Looking forward to feedback and comments from the community. We will post the scDesignPop preprint soon.
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Differential expression (DE) analysis is a key task in RNA-seq studies, aiming to identify genes with expression differences across conditions. A central challenge is balancing false discovery rate (F...
arxiv.org
Nullstrap-DE: A General Framework for Calibrating FDR and Preserving Power in DE Methods, with Applications to DESeq2 and edgeR
🔥 Congrats to @jsb-ucla.bsky.social lab for two papers accepted to the highly selective #RECOMB2026 🎉 🧪 Nullstrap-DE — FDR calibration while preserving power in DE methods 🧬 scDesignPop — population-scale scRNA-seq data generation for power + benchmarking + privacy #ComputationalBiology #Genomics