1/3 Metacells boost power in single-cell RNA-seq & multiome analysis. But without checking homogeneity, they risk forming dubious metacells that bias discoveries.
We introduce mcRigor: a statistical safeguard for rigorous metacell analysis.
š www.nature.com/articles/s41...
Aggregating similar single cells into metacells is a common heuristic for sparse data, but risks mixing dissimilar cells. Here, authors present mcRigor, which detects and filters heterogeneous metacells, optimizes metacell partitioning, and improves reliability in single-cell omics studies.
