Our manuscript on using the knot theory descriptor writhe to build kinetic models of IDP dynamics is now out in JCTC
pubs.acs.org/doi/full/10....
We think this approach establishes a new state-of-the-art for building markov state models of IDP dynamics.
The biological functions of intrinsically disordered proteins (IDPs) are governed by the conformational states they adopt in solution and the kinetics of transitions between these states. We apply wri...
Presenting one of my favorite manuscripts I've ever worked on:
"Characterizing structural and kinetic ensembles of intrinsically disordered proteins using writhe"
www.biorxiv.org/content/10.1...
by Tommy Sisk, with a generative modeling component done in collaboration with @smnlssn.bsky.social
