Introducing OpenSplice, an atlas of splice-altering variants and the largest systematic analysis of splicing regulatory variants
OpenSplice quantifies the impact of 590,000+ variants on the splicing of 608 alternatively spliced exons, and is out now on bioRxiv 🧬🖥️
www.biorxiv.org/content/10.6...
Excited to release #OpenSplice - the impact of >500,000 mutations on the alternative splicing of 600 human exons
www.biorxiv.org/content/10.6...
Led by @gioia-quarantani.bsky.social + funded by @opentargets.org ‬ @sangerinstitute.bsky.social @crg.eu
#cshlsymp26 #RNA2026 @rnasociety.bsky.social
1\ Excited to finally share some of my PhD work: OpenSplice!
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.
Great collaboration between @genomedatalab.bsky.social
at @irbbarcelona.org / @bric-ucph.bsky.social
and the @benlehner.bsky.social group at @crg.eu
/ @sangerinstitute.bsky.social
👉Read our NMDetective-AI study www.biorxiv.org/content/10.6...
AI x BIO 2026, 8-10 June
Submit an abstract now!
>450 registered last year
coursesandconferences.wellcomeconnectingscience.org/event/ai-x-b...
The allosteric landscape of the Src kinase
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
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TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Wow. Catalonia has more active clinical trials than the entirety of the UK or Germany. That's wild. From the latest @biocat.cat annual report.
Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team.
Full deep mutational scan of an entire human protein interaction domain family
2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence
More details 👇
www.biorxiv.org
Comprehensive allosteric mapping prioritizes all possible druggable surface pockets in the Src kinase for allosteric inhibition.
www.science.org
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...
OpenSplice: the impact of half a million mutations on the alternative splicing of 600 human exons https://www.biorxiv.org/content/10.64898/2026.05.22.727141v1
