Toward Excellent, Inclusive, & Open Science
Opinions are my own and do not reflect those of my employer.
Leslie B Vosshall PhD
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@hhmi-science.bsky.social meeting vibes. Brilliant @UMBC #MeyerhoffScholar undergraduate asks a probing question and Rod MacKinnon tracks them down to discuss further
📢**new pre-print article alert**
Us: OMG your entire brain is teeming with dengue virus particles
Female mosquito: [shrug][goes about daily activities]
#VosshallLab @hhmi-science.bsky.social @rockefeller.edu
www.biorxiv.org/content/10.6...
Congratulations new #VosshallLab PhDs!!
So proud of all 3 of you - you make the world better
Dr. Priyanka Lakhiani > MSKCC bioinformatic specialist
Dr. Adriana Rosas > Whitehead Institute postdoc
Dr. Yael Tsitohay > NYC public high school biology faculty
@rockefeller.edu
By "eavesdropping" on the dreaming brain, #HHMIInvestigator Massimo Scanziani's lab discovered something remarkable: During REM sleep, the brain runs an internal model of the world, simulating the consequences of actions w/no input from the outside world: bit.ly/3RwRXhI.
You asked, we answered — this time for our united #FreemanHrabowski Scholars and #HannaGray Fellows programs. A warm welcome into who's eligible, how the programs connect, and more, from our very own Science Program team members Mary Bonds & Lucy Corcoran. Applications open 11/3! bit.ly/fhs26 🧪
Celebrating #HHMIInvestigators Michael Elowitz (Caltech) & Yang Dan (Emeriti), recognized for their incredible contributions to research as newly elected Fellows of the @royalsociety.org! bit.ly/4nPHaLs
Nematodes follow their noses (er, sensory organs) just like we do — toward smells they love, away from those they don't. #HHMIInvestigator Steven Flavell & collaborators have now mapped this process neuron by neuron, giving a rare look at how brains turn sensation into behavior: bit.ly/3RcNeBp.
Beyond thrilled to welcome our inaugural cohort of #CechFellows — 176 talented undergrads who will spend 9 weeks this summer contributing to real scientific discovery alongside leading HHMI scientists across the country, & at our Janelia Research Campus! hhmi.news/4dBq7tb
Video
Leslie B Vosshall PhD
Leslie B Vosshall PhD
Dengue virus infection in Aedes aegypti mosquito brains elicits minimal transcriptional response bioRxivpreprint
Leslie B Vosshall PhD
HHMI
HHMI
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What happens in a mosquito's brain when it's infected with dengue? Almost nothing! 🦟🧠 We show DENV actively replicates in the brain, yet triggers virtually no transcriptional response. a striking case of neural tolerance ⬇️
New preprint by Umberto Palatini #Vosshalllab
www.biorxiv.org/content/10.6...
Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infe...
Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infe...
Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infected by these arboviruses, but how the mosquito nervous system responds to arboviral infection is unknown. We combined whole-mount immunofluorescence with single-head bulk RNA-sequencing to characterize dengue virus (DENV) infection in the brain of Aedes aegypti. DENV productively infects brain cells in a bimodal pattern: individual brains showed either sparse or widespread infection, with no intermediate phenotypes. An infectious blood meal altered thousands of genes, including 64 immunity genes, at 7 days post-feeding (DPF), yet active viral replication in the head did not increase the transcriptional response. Heads with and without detectable DENV showed minimal transcriptional differences, with no induction of canonical immune effectors. Despite productive infection, the mosquito brain tolerates DENV replication with minimal transcriptional response.
