Great to see Krijn’s work from @crick.ac.uk published! He developed clonal organoid lines from NSCLC tumours and PDX models. Immune evasion varied between clones from the same tumour, highlighting intratumour heterogeneity and providing a model to study it.
Rob Hynds
Online Now: Subclonal immune evasion in non-small cell lung cancer
dlvr.it
Dijkstra et al. investigate whether individual cancer subclones differ in their immune evasion capacity. They establish organoids representing distinct subclones from multi-region lung cancer biopsies. Co-culture with T or NK cells shows heterogeneity in immune evasion across different tumor subclones, demonstrating that immune escape is shaped by subclonal evolution.
