Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.
www.science.org/doi/10.1126/...
Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.
