Combining frontier AI & frontier biology to help scientists cure or prevent disease
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A newly released AI tool has generated an atlas of more than one billion predicted protein structures and billions more protein sequences.
go.nature.com/4wS3Pen
The new open-source atlas, generated by an AI tool called ESMFold2, vastly increases the known protein universe.
Applied to T cell receptors from ankylosing spondylitis and uveitis patients, the models outperformed AlphaFold3 at predicting T cell activation, and surfaced a striking candidate autoantigen: PSG5, expressed in iris tissue.
📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬
Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std?
The answer surprised us 🧵
www.biorxiv.org/content/10.6...
