Neuroscientist-cell biologist, proteomics developer, deep learning collaborator, tackling brain disorders. PI @Duke. Chair of Cell Biology and Biochem. Founder, Triangle Protein Design.
http://soderlinglab.cellbio.duke.edu
Scott Soderling
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Funny quote of the day. “No major life decisions within 30 days of:
A meditation retreat
A psychedelic experience
Your first encounter with the latest Claude model”
😂
You can use the model right now to freely generate families for single sequence inputs (i.e., diversification conditioned by intrinsic representations of evolution), or to engineer proteins based on family promts (diversification by conditioning on particular evoluationary trajectories).
Find out more: flip.protein.properties
It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.
Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment.
https://medschool.duke.edu/news/hidden-enzyme-may-explain-muscle-loss-tied-cancer-treatment-and-aging
#AcademicSky #MedSky
Scott Soderling
There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab!
www.nature.com/articles/s41...
My lab was lucky to be able to help test Proteina-Complexa binders experimentally. We were blown away by the results. Congrats to our colleagues at NVIDIA!
@rohitsingh8080.bsky.social USHER: Guiding Foundation Model Representations through Distribution Shifts
Aditya Pratapa, Purushothama Rao Tata, Rohit Singh
bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
