📢 New publication.
We answered an old question in structural biology: (how) does the crystal lattice impact proteins? In particular, how does the crystal restrict the protein's dynamics?
We used local probes of dynamics: the rotation of aromatic rings. 🧵
www.nature.com/articles/s41...
The extent to which crystal packing constrains protein dynamics is hard to decipher. Now a combination of NMR, crystallography and molecular dynamics simulations show that intermolecular contacts can ...
