Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in #cancer #immunotherapy. We spotlight promising research and attend major meetings. We also make cool images :)
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In a phase 2 clinical trial of a short-course regimen (median 7 months) of pembrolizumab (anti-PD-1) plus high-dose IL-2 in patients with advanced ccRCC, Johnson et al. reported that at a median follow-up of over 6 years, the ORR was 73%, with 42% CRs and a 92% DCR. bit.ly/4efKhYK
In mice, i.t. or i.v. delivery of CKK-E12-LNPs loaded with immune-remodeling mRNAs (IR-mRNAs) encoding NF-κB-inducing kinase (NIK) or IFN regulatory factor 8 (IRF8) induced (1) APC activation and maturation into cDC1s, (2) a release of immunostimulatory cytokines [...] bit.ly/3PJgZK1
Cho et al. integrated whole-section (WS) spatial transcriptomics across 12 cancer types to construct a pan-cancer tertiary lymphoid structure (TLS) atlas. TLSs spanned early, primary, and secondary maturation states with distinct spatial niches and immune organization. bit.ly/4dZAbwi
CCR1 expression in tumor myeloid cells plays an immunosuppressive role pancreatic cancer, and could be targeted through immunotherapy bit.ly/4v5iema
Courau et al. profiled immune landscapes of 15 common mouse tumor models alongside human datasets. bit.ly/3RK2oi1 @maxkrummel.bsky.social
In a KPC tumor model, Nguyen et al. combined a FAP-targeted CD40 agonist (FAP-CD40; localizes CD40 stimulation to the TME) and PD1–IL-2v (targets a mutated IL-2 to PD-1+ T cells and not Tregs). bit.ly/4e5iWs4
To improve CAR T cell efficacy for solid tumors, Sun and Liu et al. designed a series of CARs that enabled antigen-dependent “cytokine” co-activation, while preserving second-generation CAR structure. Incorporating compact IL-2/IL-15 receptor [...] bit.ly/4ueD7dq
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Azimazade et al. developed an explainable machine learning (XML) pipeline to study associations between clinical outcomes and in silico estimated cell types within the TIME of over 5,000 METABRIC and TCGA [...] bit.ly/4uteIkj
@younessazimzade.bsky.social
@alvarokohn.bsky.social
Navarre, Ishibashi, and Nair et al. showed that focal 8 Gy tumor irradiation in a syngeneic metastatic lung adenocarcinoma model enhanced CAR T cell persistence and efficacy in a DC-dependent manner. bit.ly/3SjHNkF @sinaiimmuno.bsky.social @jalalahmedlab.bsky.social
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