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Neuroscientist, corgi parent. Views are my own.
Yudong Gao
The most fun part of this study is to find out that a broken "beta-propeller" structure entangles Ppp2r2c at the AIS (Thanks, AlphaFold). There is a lot more work to be done to better understand the function of this enigmatic subunit - please stay tuned! Image Credit: generated by ChatGPT.
6mo
@bcmneurosci.bsky.social First paper from my new lab here at BCM Neuroscience! 😀
6mo
Yudong Gao
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
Yudong Gao
6mo
www.nature.com
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
Phosphorylation at the AIS is back! Nice work from @yudonggao.bsky.social and Matt Rasband on the presence and role of the PP2A phosphatase subunit Ppp2r2c using HiUGE tagging www.nature.com/articles/s41...
Yudong Gao
6mo
Christophe 🔬 Leterrier