We are grateful to all the authors and collaborators who made this study possible. Special thanks to everyone in the Cordero-Morales and Vásquez laboratories (especially Briar Bell, Angela Jaramillo-Granda, and Luis Romero), as well as to our collaborators.
www.science.org/doi/10.1126/... (3/4)
Here is the morph video summarizing some of the changes we found in a TRPC3 hypermorphic variant (Science Advances, Science Magazine)
(4/4)
Using electrophysiology, cryo-EM, molecular simulations, and in vivo models, we also identify a druggable inhibitory site that could guide future therapies for cerebellar ataxia.
(2/4)
A great opportunity to bring trainees, exchange ideas, and connect across disciplines. Registration is open: www.grc.org/ion-channels...
3/3
We are so happy to see Vasanthi Jayaraman named chair of Biochemistry at UTHouston
Vasanthi is not only a leader in biophysics and Editor-in-Chief of the Biophysical Journal, but also a wonderful colleague and mentor
Congratulations @frettinglab.bsky.social
med.uth.edu/blog/2026/04...
Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026.
1/3
We have an outstanding speaker lineup, including Keynote Talks by Kenton Swartz, Nancy Carrasco, Miriam B. Goodman (@wormsense.bsky.social), and Francisco Bezanilla. Trailblazer Spotlights presented by Ed Twomey (@cryoet.bsky.social)and Theanne Griffith (@doctheagrif.bsky.social).
2/3
Excited to share our new paper in Science Advances @science.org
In this work, we uncover how a disease-linked TRPC3 mutation, together with a cerebellum-specific splice isoform, stabilizes the channel in an open state, drives Calcium overload, and promotes neurodegeneration. (1/4)
