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🔍 New discoveries in cellular & molecular #immunology New #OpenAccess journal from @britsocimm

Discovery Immunology

PROS1 released by lung basal cells may help limit severe COVID‑19 inflammation and promote tissue repair, according to a Discovery Immunology study. 🧬 vist.ly/5792z #COVID19 #Immunology

Pathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬 🔗 vist.ly/55ib7 #Immunology #Autoimmunity #Tcells

T cell activation depends on rapid gene expression changes. This study shows RAM is upregulated during activation and is essential for RNA cap formation, driving protein synthesis and CD4 T cell proliferation. 🔗 vist.ly/56rbp #Immunology #TCells

CARKL emerges as a key regulator of T-cell function by driving metabolic reprogramming, shaping cytokine output, mitochondrial activity, and migration via CXCR3. A compelling link between immunometabolism and immune regulation. vist.ly/57crf #Immunology #TCells #Immunometabolism

Abatacept suppresses T cell activation, but how durable is its effect? Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬 🔗 vist.ly/55mmj #Immunology #Tcells #Autoimmunity

🧬 New insights into Treg biology! This study uncovers how periodic TCR signaling shapes self-reactive T cells and how HTLV-1 hijacks these pathways. A new 2-axis model links activation dynamics to Foxp3 regulation, opening doors for cancer & immunotherapy research. #Immunology #Tcells

Read the full collection: https://academic.oup.com/discovimmunology/search-results?f_TocHeadingTitleList=T+Cells+at+Barrier+Sites

Read the article here: doi.org/10.1093/disc...

γδ T cells in the female reproductive tract, quiet defenders or active players in pregnancy? 🤔 This review unpacks their dynamic, hormone-responsive roles at this unique barrier site ⚖️ Part of our T Cells at Barrier Sites collection🧬 vist.ly/56m3b

📢 New in Discovery Immunology New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬 🔗 vist.ly/54z8t #Immunology #Vaccines #Bcells #OpenAccess

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Discovery Immunology

Abstract. Abatacept, a co-stimulatory blocker comprising the extracellular portion of human CTLA-4 linked to the Fc region of IgG1, is approved for the tre

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AbstractIntroduction. Murine ocular autoimmunity develops through 3 stages; prodrome, primary peak and secondary regulation. During the prodromal phase, le

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The effect of abatacept on T-cell activation is not long-lived in vivo

A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases

Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?

Summary. The female reproductive tract accommodates and balances the unique immunological challenges of protection from sexually transmitted pathogens and

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AbstractBackground. Immunometabolism is a crucial determinant of immune cell function, influencing cellular activation and differentiation through metaboli

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The sedoheptulose kinase CARKL controls T-cell cytokine outputs and migration by promoting metabolic reprogramming

1. SARS-CoV-2 infection of the epithelium results in the release of IFN. 2. IFN secretion has an autocrine effect on epithelial cells. 3. Infection and IFN

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PROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection

Summary. Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to di

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Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1

Summary. The female reproductive tract accommodates and balances the unique immunological challenges of protection from sexually transmitted pathogens and

doi.org

Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?

Pseudorabies Study Overview

AbstractIntroduction. The antibody repertoire reflects the immune history of an individual. In the present study, we characterised the porcine antibody hea

doi.org