Plants, Pathogens and Procrastination
Emmy Noether Fellow at ZMBP
Juan Carlos De la Concepcion
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The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe.
📄 www.nature.com/articles/s41...
💾 folddisco.foldseek.com
🌐 https://search.foldseek.com/folddisco
We got a cover!!! Beautiful artwork by
@nicolatrozzi.bsky.social
🎨🌺🍀 @mechanobiologylab.bsky.social
@fbm-unil.bsky.social @unil.bsky.social
Video
www.nature.com
Folddisco enables protein structural motif search in million scale databases.
Second May issue is live!
link.springer.com/journal/4431...
The cover features work by Mateusz Majda @matmajda.bsky.social and Richard S Smith @johninnescentre.bsky.social showing that puzzle cells transform cell geometry into a living record of how leaves grow.
link.springer.com/article/10.1...
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
Video
Cool article:
Mass extinctions and land plant evolution
The big five - five mass extinctions and their importance for plant evolution.
www.cell.com/current-biol...
EMBO Reports
Martin Steinegger 🇺🇦
Today marks 30 years since we identified the apicoplast, a relict plastid in human and animal parasites (PMID 8632819). Apicoplasts are the target of the widely used antimalarial prophylactic doxycycline, which has saved many thousands of malaria infections.
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature.
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
Ralf Reski
For liverwort mavens, I've needed to shift our Marchantia resources to a new website (I've reached retirement from academia in Cambridge) - and the plant synthetic biology stuff has moved to https://www.haseloff-lab.info
(Now have more time for DIY builds! Updates to come)
You saw them first on @bioRxiv.
Now they’re out in print—back-to-back.
Meet AVRcap1b: the two-faced immunosuppressor from the potato blight pathogen Phytophthora infestans.
www.science.org/doi/10.1126/...
Mitochondria directly interact with the nuclear pore complex!
www.nature.com/articles/s41...
As seen on @biorxivpreprint.bsky.social: our story on how the dreaded late blight pathogen hijacks a helper NLR pathway is now out in its final form! 🎉
Meet AVRcap1b: the two-faced effector 🧵👇
www.science.org/doi/10.1126/...
A plant pathogen effector suppresses an activated helper NLR via a host ENTH domain–containing protein, NbTOL9a.
