Our group develops and applies computational approaches to study molecular variations and their phenotypic consequence. We are part of DKFZ and EMBL.
Website: https://steglelab.org/
Stegle Lab
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Grateful to editor @linkonrg.bsky.social and artist Patrick Morgan for translating these concepts into a compelling visual narrative, to all collaborators and those who have contributed to our living catalogue of single cell perturbation methods: interp-extrap-perturb.readthedocs.io/en/latest/me...
The cell is the ball, the bumpers are causal signatures shaping its path, and the flippers are the emerging methods that guide our understanding as it moves through the complex molecular terrain.
Link to our review: doi.org/10.1038/s415...
Are you ready to play our special version of pinball? 🕹️
This cover of @natrevgenet.nature.com was inspired by our review on the interpretation, extrapolation and perturbation of single cells.
The artwork takes the form of a pinball machine, as a deliberate reimagination of Waddington's metaphor.
Join us for a postdoc in AI in human genetics at @embl.org in close collaboration with Adrian Cortes (GSK) and @brianfclarke.bsky.social - exploring the effects of rare variants using population-scale cohorts and single-cell readouts.
🔗 Apply now: embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Welcome @bbbranjan.bsky.social! His career across single-cell genomics, 🐁 biology and software dev has been about bridging wet-lab with reliable analysis workflows. At @embl.org he will lead a collab with @vrmlnroel.bsky.social on modelling GxE interactions to dissect risk factors for human disease.
Two weeks ago, MAIGE group leader @brianfclarke.bsky.social and Katharina, together with Dominik (Steinmetz lab) joined #Perturb2026, exploring new technologies and datasets. Highlight: Katharina’s first short talk on large-scale perturbation screens in cardioids and great discussions at our poster!
