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CREsted is finally out! You can find the article, together with a summarizing Research Briefing, in thread. 🦎
Latest from Shendure & Qiu labs (@cxqiu.bsky.social) )! We combined a new 4M cell mouse whole embryo scATAC-seq atlas (E10-P0), millions of 'evolutionarily coherent' orthologs from 241 mammalian genomes (Zoonomia), and the CREsted CNN framework (@steinaerts.bsky.social).
2mo
2mo
Excited to share our new paper @nature.com! We developed PerturbFate, a scalable single-cell platform to discover how diverse genetic perturbations converge on a shared drug-resistant cell state, and key programs driving it, led by our incredible Zihan Xu from @rockefeller.edu rdcu.be/fdC14
2mo
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Niklas Kempynck
Jay Shendure
Junyue Cao
CREsted: an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers. www.nature.com/articles/s41...
2mo
www.nature.com
CREsted is an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers across diverse species.
CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species - Nature Methods
Nature Methods