We are a research laboratory at the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland focusing on cell-free synthetic biology, synthetic cell engineering and microfluidics.
Maerkl Lab
Saeed's latest paper is now out on bioRxiv:
"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins"
www.biorxiv.org/content/10.6...
Maerkl Lab
Maria's paper on characterizing trans-properties of transcription factors and how they affect gene expression is out now!
www.biorxiv.org/content/10.6...
Hello World !!
The Maerkl Lab is now on Bluesky...
#syntheticbiology #cellfree #microfluidics #transcriptinalregulation
Saeed's paper is now published:
"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins"
www.nature.com/articles/s41...
Laura and Jiami's paper is out now on BioRxiv! Nice collaboration with the Reddy lab at ETHZ:
"High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping."
www.biorxiv.org/content/10.1...
Check out Amogh's latest review:
"Microfluidics meets cell-free systems: from molecular engineering to synthetic cells"
now published in Current Opinion in Biotechnology.
www.sciencedirect.com/science/arti...
Pao-Wan and co's paper is published now as well !
"A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications"
www.nature.com/articles/s41...
Maerkl Lab
High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping https://www.biorxiv.org/content/10.1101/2025.09.23.678000v1
Maerkl Lab
Building a self-replicating biochemical system remains a challenge in synthetic biology. Here the authors demonstrate that the cell-free protein synthesis PURE system can be reconstituted from protein...
T7 RNA polymerase is widely used in synthetic biology, but tools to precisely regulate it are limited. Here, authors engineer a modular T7 RNAP regulatory toolbox for programmable repression, activati...
SARS-CoV-2 variants continue to threaten public health, necessitating the study of cumulative and epistatic effects of receptor-binding domain (RBD) mutations on antibody evasion. We present a high-th...
