Took me a while to read but this post by Peter Kenny is well worth the time.
fbdd-lit.blogspot.com/2026/01/hit-...
Congrats to Emilien, Maurus and Giorgia! Metal- and CO-Free Carbonylation of Alkyl Iodides @jacs.acspublications.org pubs.acs.org/doi/abs/10.1...
Michael Bogdos
Congrats to @mixalhsmpogdos.bsky.social, @sevenroediger.bsky.social, @fruepp.bsky.social, Nathalie, Patrick, Fabio and Jan on this epic study of C-N red. elim. in @jacs.acspublications.org - using causal inference, organometallics, electrochemistry, kinetics and DFT. pubs.acs.org/doi/full/10....
When researchers bring up confounders without ever having declared the actual analysis goal
Continuing our campaign to study all the alkali metals in organometallic chemistry. Why don't you try this in your own studies? Our friends in Bern @evaheviagroup.bsky.social are!
Comparisons and Contrasts in a Complete Set of Alkali Metal Cumyl Structures | Inorg Chem pubs.acs.org/doi/10.1021/...
Morandi Research Group
Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...
Alkali-metal benzyl complexes derived from toluene are known to vary their metal–ligand coordination mode as a function of the alkali-metal, with the metal transitioning from a typical σ bond to the anionic CH2 for lithium toward an interaction with the delocalized pi system of the aromatic ring as the metal gets larger and softer. Here, by switching to cumene, we report the charge-localizing effect of replacing the hydrogen atoms at the formally carbanionic carbon CH2 with electron-donating methyl groups in C(Me)2. NMR spectroscopic studies reveal competitive ring-metalation occurs, at the meta and para positions, alongside α-metalation on using an alkyl lithium base, with the meta- and α-isomers crystallographically characterized as a solvated dimer and monomer, respectively. Using Lochmann-Schlosser type base pairs to access the heavier alkali-metal complexes unveils only α-metalation. The presence of the methyl groups limits the variation in metal–ligand bonding, their electron-donating properties forcing the delocalization of the negative charge into the ring resulting in M-Ph interactions and sp2 hybridization at the formally deprotonated α-carbon regardless of the metal used. Considerable variation in aggregation state is observed with monomeric (Na), polymeric (K, Cs) and tetrameric (Rb) motifs identified in the solid-state.
It's Friday afternoon (somewhere) so time for a take.
One of my issues with what is often called "hard sci fi" is that it mainly focuses on accuracy in physics but will neglect basic chemistry (I'm sure it also neglects other subjects like biology and the like as well, but let me stay in my lane).
fbdd-lit.blogspot.com
I'm now in Trinidad and I'll share a 180° panorama from Paramin where I walk for exercise. This district in Trinidad's Northern Range is ren...
Acetaldehyde (AA) is a reactive aldehyde primarily produced in cells as a metabolic intermediate during ethanol oxidation. Excess AA, often resulting from impaired AA detoxification, leads to aberrant...
