Postdoc @ Garvan Institute | Epigenetics, development, evolution
Allegra Angeloni
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Capolavoro 🎨 alert 🚨! What is the role of gene body methylation in invertebrates? Despite extensive speculation linking it to plasticity and environmental responses, its mechanistic effects and heritability remain unclear. Our take out in @natecoevo.nature.com: www.nature.com/articles/s41... 1/
🚨 We discovered a new mode of Hox gene regulation in annelids! 🪱 A distal enhancer acts as a "global control region", lifting Hox genes from Polycomb repression. This is reminiscent of Hox gene control in vertebrates, but the two modes likely evolved convergently.
www.biorxiv.org/content/10.6...
Please re-circulate. New postdoc position available to study organ positioning in the flower at the University of Sydney. Cell polarity, auxin etc etc! Join our multidisciplinary RESYDE (www2.hu-berlin.de/resyde/) team! Apply here: usyd.wd105.myworkdayjobs.com/en-US/USYD_E...
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
Facial diversity in birds and mammals doesn’t just come from different signals – but from how cells respond to them. A new study in Science Advances shows evolution acts on both: signal placement and cellular interpretation.
More Info: www.evolbio.mpg.de/3879733/news...
@marketa-kau.bsky.social
Over the moon to see this work from my PhD finally published in Development! Using a combination of structural biology and genetics we identify an avidity-driven mechanism of BMP signal control in the extracellular space. (1/11)
Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes
Cambridge → Boston → Cambridge again: I’m thrilled to return to Cambridge(UK) to open my lab at the Gurdon Institute, University of Cambridge!🥳
(mzhulab.com)
We study how dev timing shapes and being shaped by plasticity, evolution & ageing.
🚩Hiring at all levels: pls email me if interested!📩
Wrote a short piece on Transposable Elements as catalysts of evolutionary innovation for a forthcoming special issue of @naturerevgenet.bsky.social on, duh, Evolutionary Innovation!
www.nature.com/articles/s41...
Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6...
1/9
Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...
In this Comment, Cedric Feschotte highlights evidence from diverse lineages showing that transposable elements are key drivers of evolutionary innovation, repeatedly introducing regulatory and coding ...
An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation
Read this Research Article from our special issue #DevSIextracellular by @garethmoore.bsky.social, @hilaryashe.bsky.social & co from @mcf-uom.bsky.social.
journals.biologists.com/dev/article/...
#Drosophila
