Assistant Professor in the TB Modelling Group at LSHTM modelling TB vaccines👩🏼💻💉📚🇨🇦🇬🇧
Rebecca Clark
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And thanks to The Pediatric TB Contact Studies Consortium!
@tb-lshtm.bsky.social
@lshtm-tbmod.bsky.social
@cmmid-lshtm.bsky.social
@lshtm.bsky.social
@satviuct.bsky.social
@busph.bsky.social
@mcgill.ca
@isglobal.org
Inclusion of young adolescents in policy development for new #tuberculosis vaccines www.thelancet.com/journals/lan... (open access) @lancetgh.bsky.social
Overall, we highlight that the benefits and challenges of including young adolescents should be considered in TB vaccine policy so that no one is excluded from the direct benefit that vaccination can provide.
Potential advantages of including young adolescents may be
✅ the ability to vaccinate before the age-related increased risk of TB disease
✅ the possibility to align vaccine delivery with other adolescent based vaccines, such as HPV
(potential advantages continued)
✅ modelled population level impact could increase if the vaccine was effective in both those infected and uninfected at the time of vaccination
(potential challenges continued)
⛔️ lack of sensitization to Mtb in young adolescents, which may make immunobridging from vaccinated adults difficult as efficacy data will not be available for adults who are Mtb unsensitized
However, some challenges of including young adolescents may be
⛔️ low TB case accrual, which could make conventional efficacy trials costly and lengthy
⛔️ low modelled impact of vaccine delivery if the vaccine is only effective in individuals with Mtb sensitization at vaccination
Poverty is a major driver of TB.Conditional cash transfers combined with counselling improve pre-treatment loss to follow-up.In this economic analysis our modelling projections show that this intervention is cost-effective and can reduce incidence and mortality.
www.sciencedirect.com/science/arti...
Thanks to all the coauthors involved in this work
Mark Hatherill
Leonardo Martinez
Andrew Fiore-Gartland
@agbasteiro.bsky.social
Gavin Churchyard
Molebogeng X Rangaka
@mbehr-mcgill.bsky.social
Thomas Evans
Vidya Mave
Philip C Hill
Willem Hanekom
Frank Cobelens
@richardwhite321.bsky.social
New publication now out in @lancetgh.bsky.social!
New #TB #vaccines are being trialled in older adolescents and adults, and we comment on the advantages and challenges of including younger adolescents who have historically been excluded.
www.thelancet.com/journals/lan...
The infant tuberculosis vaccine, BCG, prevents severe tuberculosis disease, but protection
is rarely durable beyond childhood. New tuberculosis vaccines are being developed
for the prevention of infec...
