This project actually took a long time. One of the first questions we studied using this idea was this paper, which used structural modeling and ancestral sequence reconstruction to examine ligand-receptor (sex peptide, SPR) evolution. academic.oup.com/mbe/article/... @official-smbe.bsky.social
Abstract. Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide binds to the sex peptide r