Get out your Camera (2). This study published in 2020 (showed that combo therapy was not associated with improved outcomes and was stopped early due to increased adverse effects nephrotoxicity). So up front dual therapy not great. Salvage therapy though? Less clear jamanetwork.com/journals/jam...
This randomized trial compares the effect of combining standard antibiotic therapy (intravenous vancomycin or daptomycin) with an antistaphylococcal β-lactam (intravenous flucloxacillin, cloxacillin, or cefazolin) vs standard therapy alone on a composite outcome of mortality, bacteremia, relapse, or...
