It's out! The LIN code approach for genomic taxonomy of microbial strains and its applications in genomic epidemiology journals.plos.org/plosbiology/...
Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme...
Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance
What if multireplicon plasmids are not an oddity, but an evolutionary strategy?
We found that they are common, more mobile, broader-host-range, and enriched in AMR.
Even more interesting: their assembly doesn’t look random. 👀
Paper preprint: www.biorxiv.org/content/10.6...
Thread below!🧵👇
Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part
doi.org
Unified bacterial strain taxonomies are needed for coherent communication of findings in microbiological research. This Essay provides an overview of a novel bacterial strain taxonomy and describes ho...
🧵 New preprint out! We asked: what happens to gut bacteria when the intestine is under chronic inflammation (IBD)? Turns out, the host's inflammatory state reshapes how they evolve, and the results are pretty striking. A thread 👇
www.biorxiv.org
Phage constrain multidrug resistance spread
#Phage #Plasmid #AMR #EvolutionaryBiology #CraigMacLeanLab
The final version of our paper is out in @isme-microbes.bsky.social
academic.oup.com/ismej/articl...
bsky.app/profile/dani...
More exciting phage and plasmid research coming soon!
Marta Lourenço
Young Talents session is ON.
First up: Manuel ARES ARROYO, Pasteur-Roux-Cantarini fellow @pasteur.fr in the lab of @epcrocha.bsky.social, unraveling how genomic islands move and drive both pathogenicity and AMR spread. #AMR
@ibeidlabex.bsky.social
A new family of rolling-circle replication endonucleases widespread in archaeal viruses and plasmids. This family is unrelated to the HUH superfamily Reps, but distantly related to the bacterial Rep_trans enzymes.
@narjournal.bsky.social
academic.oup.com/nar/article/...
This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out!
doi.org/10.1038/s414...
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
Daniel Cazares
Abstract. Phage therapy offers an alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are promising the
Bacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...
doi.org
Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.
Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme...
Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance
Mart Krupovic
Mart Krupovic
Marie-Eve VAL
Zamin Iqbal
Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part
