We would have never published a paper (see thread) if not for a control that delivered a surprise - that I didn’t believe at first and asked Danae to repeat multiple times before realizing she was on to something. 1/
Dirk-Jan Scheffers 🟥
'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.'
link.springer.com/article/10.1...
EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.