a sort of scientist. viruses and antibodies. structure and biophysics. mass spec and cryoEM
Joost Snijder
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New preprint on the current bottlenecks of deep learning-based methods for de novo peptide sequencing that underuse physical properties of spectra and how to overcome this with MemNovo: arxiv.org/abs/2606.11868
#Ebola: DRC is reporting 29 new confirmed cases, 4 already dead. The DRC total now stands at 837 confirmed cases, 196 deaths. DRC reports that yesterday it followed up 64% of known contacts, but the total number of known contacts is very low, given the size of this outbreak.
No new Uganda cases.
Scientists are actively researching ways to make phage therapies more effective. This includes efforts to engineer phages to expand their host range and aid in bacterial defense system evasion.
More at Molecule of the Month: pdb101.rcsb.org/motm...
Denken lijkt wel verboden. De plannen voor de Europese economie mogen vooral niet worden tegengesproken.
Column! Vandaag zonder paywall.
www.groene.nl/artikel/
Excited to share the very first #preprint since I started my lab at @utrechtuniversity.bsky.social We explored the area of small molecule- #RNA interaction, and present SOLiD-MaP: a #photoproximity labeling platform for mapping small molecule binding site on RNA.
www.biorxiv.org/content/10.6...
Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...
wow
I recently had the pleasure of speaking with Teddy Rosenbluth at The New York Times about our work on measles. The article covers our efforts and those of others in the field who are working toward anti-measles therapeutic solutions. You can read it here: www.nytimes.com/2026/06/11/w...
Glad to see the work of my PhD on the manchette microtubule now out in @embojournal.org: doi.org/10.1038/s443...
Does Bundibugyo virus, now causing the devastating outbreak in DRC and Uganda, differ in important ways from Ebola virus? Scientists aren’t sure.
“You can read the entire Bundibugyo literature in an afternoon,” says virologist Jens Kuhn.
My story in @science.org:
The manchette is a transient microtubule (MT)-based structure that is vital for the correct shaping of sperm during spermiogenesis. Throughout spermiogenesis, the manchette retains structural integrity for several days, raising the question of how its MTs are regulated. Here, using cryo-electron tomography of manchettes isolated from rat testes, we find that manchette MT ends are structurally diverse. We show that the MT-binding protein CLASP2 is present throughout the manchette and likely regulates both MT ends. Using cryo-electron microscopy single particle analysis and super-resolution microscopy, we reveal that SPACA9 and MNMIP1 (SH3D21) bind to the seam of manchette MTs from the luminal side. SPACA9 binds to both α- and β-tubulin of protofilament 1 but does not interact directly with protofilament 13, while MNMIP1 binds directly to protofilament 13. MNMIP1 further extends and threads through the MT lattice at the seam. Our study reveals a novel seam MT inner protein complex with a unique binding mode, providing a plausible explanation for MT regulation that maintains manchette integrity over an extended period.
De Kapitaalunie, ‘Made in Europe’, het ‘28e regime’ – het zijn ingewikkelde termen voor plannen die vooral de macht van grote bedrijven lijken te vergroten.
De novo peptide sequencing from tandem mass spectrometry is pivotal in proteomics, enabling identification of novel peptides without reference databases. While recent Transformer-based encoder-decoder...
arxiv.org
The Bundibugyo virus only emerged twice before. Now, scientists see a chance to get to know it better
RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approache...
Continuous recording beam image shift speeds up single particle and tomographic data collection.
www.nature.com/articles/s41...
The authors report continuous recording beam-image shift (CR-BIS), a continuous recording strategy that overcomes camera delays to markedly accelerate cryo-EM data acquisition, improving throughput fo...
