Biophysicist / cytoskeleton in vitro
🏙 Paris @CytoMorphoLab
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... a phase separation process / spinodal decomposition.
So we teamed up with Sudipta and JF from @college-de-france.fr @institutcurie.bsky.social and wrote a Cahn Hilliard like model: a free energy of non interacting motors + active currents due to transport along MTs.
The result: spinodal-ish
It works - and we can do some theory on it. For example, we find conditions leading to (very) slowed down domain coarsening through activity (movie here)!
And also microphase separation, phase diagrams, eigenvalues... find everything on the @arxiv.bsky.social preprint!
arxiv.org/abs/2604.01057
Remember this? share.google/rfxANeClLmZN...
We showed that opposing motors mixed with microtubules from domains because they move in opposite directions on filaments. The process is based on active transport, not on direct interactions between different motors!
But the movies look a lot like..
New preprint out:
arxiv.org/pdf/2604.01057
Together with JF Joanny and Sudipta, we introduce a "new" kind of active phase separation inspired by experiments with motors and microtubules and based on transport of species along a polar "pump"!
@manuelthery.bsky.social @lblanchoin.bsky.social
And here's my small contribution, an actin dynamic state that continuosuly contracts, on the roof of the museum!
Some more snapshots :-)
Go right or left? A question that we encounter very often in our daily lives, and while our decision may sometimes be hindered by the fear of making a mistake, cells DO NOT HESITATE!!! They swirl with the confidence of someone who’s always RIGHT… or LEFT!!!
@ghinabadih.bsky.social 's paper on cell chirality is now out : www.pnas.org/doi/10.1073/... 🥳
Dress like your data like @timonnk.bsky.social does!
arxiv.org
Alfredo Sciortino
Alfredo Sciortino
Video
Alfredo Sciortino
Video
Alfredo Sciortino
Alfredo Sciortino
Video
Alfredo Sciortino
Video
This weekend we projected cells and filaments on the roof of the @museeorsay.bsky.social in Paris, then we contracted it with a pinch of myosin.
And it was fabulous!
Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab
Alfredo Sciortino
Alfredo Sciortino
Ghina BADIH
Chirality is a conserved biological feature with critical implications in tissue morphogenesis
and embryonic development. In culture, multicellular...
