KorB functions as a CTP-dependent DNA-sliding clamp traveling a long genomic distance. Sliding KorB is captured and locked in place by a partner protein, KorA, forming a stable A-B complex at target promoters to repress transcription.
TrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids https://www.biorxiv.org/content/10.64898/2026.05.27.728120v1
Here, @tommclean.bsky.social shows that another RK2 regulator, TrbA, likely also use this “clamp sliding-locking” mechanism to regulate gene expression. Interesting how a single sliding clamp might integrate multiple partners to potentially build a complex regulatory network...
shorturl.at/YQJOI