ER-phagy orchestrates virus–host interactions across kingdoms
Beyond maintaining endoplasmic reticulum (ER) homeostasis, ER-phagy (or reticulophagy) serves as a conserved antiviral defense across kingdoms. By targeting viral replication organelles and degrading viral components, it restricts infection, while viruses counteract or exploit this pathway. This dynamic interplay shapes infection outcomes and highlights ER-phagy as a promising target for antiviral intervention.
