Assistant Professor at University of Warwick
Leading FMD Lab: https://fmd-lab.org/
Postdoc in Fraser Lab (USC)
Postdoc Fritzsche Lab (Oxford)
PhD in Eggeling Lab (Oxford)
Into all things Biophysics, Fluorescence, and Membranes
https://faldalf.github.io
Falk Schneider
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✨Rare model organisms can teach us how to build a body differently. In snail embryos blastomeres can be as big as the rest of the embryo! 🐌Phrontis vibex blastula stained for tubulin (gray), phalloidin (blue) and histone (magenta). 🔬
#ModelMonday #DevBio
📸: Clemens Cabernard
Preprint Alert🚨🚨🚨
TPE FLIM of NAD(P)H is a promising readout for cellular metabolic changes.
Wouldn’t it be great to multiplex it with fluorescent proteins marking other structures or specific cell types?
YES!
Unfortunately, this seems surprisingly hard 🤔😅:
www.biorxiv.org/content/10.6...
Video
Falk Schneider
Society for Developmental Biology
A bit late, but plasmids for cloning-free PCR donors for endogenous gene Knock-In in fish are available on Addgene
www.addgene.org/browse/artic...
What if light could help doctors see disease sooner? 🔬
This updated review explores advances in medical hyperspectral imaging, from improved sensors to AI‑powered analysis, showing how richer light data can support better diagnosis & surgical guidance. Read more in #SPIE_JBO: https://bit.ly/42ncbMO
2/🧵 SPARK (Simulation of Protein Accumulation from Reaction Kinetics) takes in experimentally-measurable binding site information and molecular kinetic parameters and generates molecular trajectories. It outputs simulated microscope images under user-defined imaging conditions (mag, exposure, etc.)
Did you know that stem cells have unusually large transcription clusters, which disappear upon differentiation? Yes? You paid attention in 2018!
In 2026, we show you that this process proceeds via massive, global shifts in transcriptional control.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
A new paper from the LOB microscopy unit on high-speed multiphoton light-sheet imaging has been published in Optica. We achieved kilohertz frame rates by enhancing the signal-to-photodamage ratio during live imaging. doi.org/10.1364/OPTI...
Alexandre Paix
New PhD opportunity in my lab📣!
The PhD studentship* will be embedded in a broader project looking at glioblastoma from a mechanobiological angle, funded by a recently granted Springboard award from the @acmedsci.bsky.social 🙏.
*only home student fees covered
👉 www.findaphd.com/phds/project...
SPIE
Lennart Hilbert
Mir Lab
Laboratory for Optics and Biosciences
If you see this image and think "ha, fly testis!", you know your stuff.
If you also know how transcription clusters form and disperse during sperm precursor formation, maybe don't read our new Advanced Science paper, out today 😉
advanced.onlinelibrary.wiley.com/doi/10.1002/...
1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...
PhD Project - Leveraging mechanobiology for the dissection of stem-like properties and therapeutic resistance potential in glioblastoma cells at University of Strathclyde, listed on FindAPhD.com
