PhD student in F.U.Hartl group - MPI of Biochemistry | Molecular cell biology | Single particle tracking | Proteostasis | Chaperone mediated protein folding
Niko Dalheimer
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New from our lab @crick.ac.uk.
Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones.
Which chaperones recognise specific nascent chains, and what dictates their binding preferences?
www.biorxiv.org/content/10.6...
Nature research paper: Single-molecule dynamics of the TRiC chaperonin system in vivo
go.nature.com/4qZM3Cn
The new publication "Stages of biomolecular condensate formation in pro-β-carboxysome assembly" from the Manajit Hayer-Hartl team is out at Nature Plants!
❕ Publication: www.nature.com/articles/s41...
#Rubisco #carboxysome #cyanobacteria
"Single-molecule dynamics of the #TRiC #chaperonin system in vivo" is out @nature.com.
❕Publication: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/live-broadca...
Authors: @rongqinxiaoxiao.bsky.social, @niko-dalheimer.bsky.social, @mamueller.bsky.social, F.-Ulrich Hartl
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
All lights on protein folding 💡
Out @nature.com , @niko-dalheimer.bsky.social & @rongqinxiaoxiao.bsky.social from the Hartl lab at @maxplanck.de Institute of Biochemistry developed single-particle tracking in living cells to study the dynamics of co-translational protein folding
#sciart #scicomm
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
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Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
Carboxysomes are cyanobacterial CO2-concentrating compartments with a proteinaceous shell. The elucidation of the role of the shell adaptor protein ApN in stepwise β-carboxysome assembly will aid the ...
