Here is a small comparison chart so you can see just how much a neutral expression alone can change by simply modifying the size of the pupils. All these are 100% vanilla faces with vanilla eyes. Left is the original, right is the scaled pupils.
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I was talking to a friend ingame about gposing and this is something they were unaware of, so I figured more people might not know. In brio, ktisis and C+ there's these two bones (j_f_irisprm_r & j_f_irisprm_l) that allows you to scale your character's pupils without affecting the size of the irises
