Now online! Metabolically regulated proteasome supramolecular organization in situ
Updated architectural model of the NPC from our lab, starred by bsky-less Agnieszka Obarska-Kosińska. Using cryo ET, XL-MS and modeling, we identify novel nucleoporins, among those the mRNA export complex TREX-2! Check out the preprint on biorxiv #TeamMassSpec #TeamTomo
Komm’ am 12. Juni auf die Night of Science✨! Erlebe, wie aus Stickstoff leckeres Eis🍦wird und welche Aufgaben verschiedene Proteine in unserem Körper übernehmen! Erfahre in Vorträgen und bei einer Elektronenmikroskopie-Tour 🔬 mehr über unsere Forschung! Infos: 👉 www.biophys.mpg.de/de/night-of-...
Out now in Nature Communications!
We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky
www.nature.com/articles/s41...
Structural steps along the assembly of proteasome storage granules—membraneless organelles that form in response to metabolic shifts in yeast—are visualized inside cells by cryo-electron tomography. Inactive 26S proteasomes oligomerize into trimers, which assemble into paracrystalline arrays that serve as reservoirs of fully assembled proteasomes under conditions of low energy, ready for reactivation when glucose is restored.
Great team effort together with @jpkreysing.bsky.social @yuningwang.bsky.social @deglushk.bsky.social Agnieszka Obarska-Kosinska @pchoffmann.bsky.social Stefanie Böhm Alex Schmidt @meiercredo.bsky.social Julian Langer @hummerlab.bsky.social and guided by @becklab.bsky.social!
Ready to TANGO? 💃 In our new publication, Beata Turoňová & Markus Schreiber (@ms314.bsky.social, @becklab.bsky.social) present TANGO: the first cryoET framework to analyze the relation between particle positions and orientations 🪩 All in a single user-friendly package! #CryoET #OpenScience
