We are delighted by the publication of our work identifying human LBR and LAP2 as key heterochromatin tethers at the nuclear envelope.
Their loss massively changes 3D chromatin organization, and causes defects in epigenetic maintenance and cell fate determination.
doi.org/10.1038/s415...
Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...
