//
sign in
Post
by @danabra.mov
PostEmbed
by @danabra.mov
Record
by @jimpick.com
Record
by @atsui.org
+ new component
Post
Thrilled to see our study out in Science Advances 🔥 www.science.org/doi/10.1126/...
29d
A threshold-based phospho-switch of DVL mediates Wnt signaling and rationalizes DVL’s domain architecture.
www.science.org
A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling
Bryjalab
Excited to share our new preprint on bioRxiv. 🎉 We uncovered a Wnt-induced phospho-switch of Dishevelled. This intramolecular coupling is mutually exclusive with FZD engagement and functionally required for the Wnt/β-catenin signaling. 🧵 doi.org/10.1101/2025...
8mo
Bryjalab
When Wnt ligands bind to Frizzled (FZD) receptors, Dishevelled protein (DVL) gets multiphosphorylated by Casein kinase 1 (CK1). Although, it is well known that DVL phosphorylation relays Wnt signals f...
doi.org
A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling