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We worked on ChREBP, we work on aging. Now Hager et al. (@umich.edu) report opposite ChREBP regulation in liver and brown adipose tissue of five mouse models with extended longevity, indicating tissue specific lipogenesis contributes to aging. American Aging Association doi.org/10.1007/s113... 🧪
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GeroScience - De novo lipogenesis (DNL) is a metabolic process by which carbohydrates are converted into fatty acids and used for immediate energy or stored as triglycerides for later use....
doi.org
ChREBP-mediated regulation of lipid metabolism in liver and brown adipose tissue of long-lived mice
Adlung Lab