Inhibiting hepatic ALP robustly enhances metformin’s hypoglycemic effect in diabetic disease models.
#LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.05.012
Ye et al. uncover that fatty liver exacerbates hyperglycemia through hepatocyte-to-intestinal stem cell remote communication driven by the ALP-α2δ-1/CaV1.2-SOX21 axis via the calcineurin-NFATC2 signaling cascade, which regulates ISC differentiation and glucose homeostasis in vivo. They find inhibiti
