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Structural biochemist and evolutionary microbiologist 🇺🇸 MIT / Brandeis University Formerly 🇬🇧 MRC LMB / University College London 🇧🇷 University of São Paulo / University of Brasília
Diorge Souza
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How do bacteria avoid killing their own siblings while using contact-dependent weapons? In this work, a conserved DUF4189 protein (Xac2611/Tpf) blocks X-T4SS mediated killing, likely via interaction with VirB5. Great work led by my friend @okagu.bsky.social at the @chuckfarah.bsky.social lab
1mo
Diorge Souza
Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)! They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor. With several recent related preprints, it’s an exciting moment for the field!
3mo
Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)
3mo
A fantastic position! The dream place to do science! 🤩
A conserved archaeal ribosome-associated factor linking bacterial hibernation and eukaryotic energy sensing pubmed.ncbi.nlm.nih.gov/41757010/ #cryoEM
3mo
3mo
Alex Bisson
Vikram Alva
A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...
Diorge Souza
cryoEM papers
3mo
www.biorxiv.org
Diorge Souza
A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...
3mo
www.biorxiv.org
Diorge Souza
Happy to share our new bioRxiv preprint: “To Kill or not to Kill: A Conserved Trans-Intoxication Protection Factor Blocks X-T4SS-Mediated Fratricide through Interaction with VirB5” www.biorxiv.org/content/10.6...
1mo