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Orforglipron is beneficial for blood glucose control in individuals with type 2 diabetes using metformin or taking insulin glargine, according to two studies published online June 8 in The Lancet and the JAMA to coincide with the annual meeting of the American Diabetes Association, held from June 5 to 8 in New Orleans.

A study led by Georgia Institute of Technology's Associate Professor Costas Arvanitis takes a major step toward safer and more effective treatment and diagnosis of brain diseases. His team's research, published in Advanced Science, shows how combining artificial intelligence (AI) with focused ultrasound can safely deliver therapies and improve diagnostic interventions to the brain.

The COVID-19 pandemic disrupted routine health care in unprecedented ways, forcing providers and patients alike to delay or forgo preventive services. At the University of Colorado Anschutz School of Dental Medicine, those disruptions allowed a team of oral health and informatics researchers to better understand what happens when routine periodontal maintenance is paused, and what those findings mean moving forward.

A new JAMA study finds that federal efforts to expand the physician workforce fall short for primary care and rural communities, despite clear policy goals. The findings raise pressing questions about whether current implementation strategies can effectively address longstanding physician shortages across the U.S.

It is a common misperception that electrocardiograms (ECGs) simply contain data about heart activity. However, modern ECGs enhanced with artificial intelligence (AI) can contain data about a patient's sex, age, race and even exact identity derived from ECG signals, raising fresh privacy concerns. To address these worries, researchers from the University of Kansas have developed a privacy-preserving AI model called (PP-VAE) to protect personally sensitive data.

Intrahepatic cholestasis of pregnancy (ICP) affects approximately 0.2–2% of pregnant women and typically develops after 30 weeks of gestation. As the most common symptom is severe itching of the palms and the soles of the feet, the condition can often be identified during routine prenatal care. The diagnosis is confirmed by elevated liver enzyme levels and increased concentrations of bile acids in the blood. Although the condition usually resolves after delivery, it is associated with an increased risk of complications, including preterm birth and stillbirth.

A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become popular for weight loss, but results vary from person to person and from drug to drug. Venky Soundararajan and colleagues explored the full range of responses to tirzepatide (e.g., Mounjaro or Zepbound) and semaglutide (e.g., Ozempic, Wegovy or Rybelsus) by analyzing de-identified electronic health records for matched cohorts of 10,339 tirzepatide-treated and 10,339 semaglutide-treated patients. In the real world, outcomes ranged from minimal weight loss to more than a 25% reduction in body weight.

Cancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, fueling drug resistance and disease progression.