A new Nature study from Duke reveals that GPCRs signal through liquid-like protein clusters formed by β‑arrestins—an unexpected mechanism with implications for drug development.
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https://medschool.duke.edu/news/new-study-reveals-droplet-mechanism-behind-key-drug-targets
Duke researchers Sundarshan Rajagopal, MD, PhD, and MD-PhD student Preston Anderson have worked together to realize how G protein-coupled receptors signal through liquid-like protein clusters that cou...