Aging killifish show systemic inflammation and accumulating DNA damage in progenitor-like immune cells, offering a window into the evolutionarily conserved mechanisms of vertebrate immune aging.
Great work from Gabriele, @mdonertas.bsky.social, and the whole team.
www.nature.com/articles/s43...
Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...
Our group has a new home on the web that does the work justice ✨
donertas-group.github.io
Huge thanks to Prasoon for building it 🙏
It's a super nice snapshot of where the field stands and where we think it's heading. Thanks to the Nature Aging editors for bringing our perspectives together!
Every time a journal makes me convert my .csv/.tsv supplementary files to Excel, a little piece of open science dies🥀 RIP reproducibility, my floating-point precision, and at least a dozen genes that are now formatted as dates.
Reading through everyone's responses, a few recurring themes emerge: epigenetic clocks and multi-omics have transformed how we measure aging. But translation from model organisms to humans remains hard, and effect sizes that look dramatic in mice often don't hold up in people.
