PAIN is the official publication of the International Association for the Study of Pain (IASP). PAIN publishes original research on pain and provides a multidisciplinary forum for the dissemination of basic and applied pain research.
PAIN
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Wang et al. find that self-induced attenuation varies by stimulation modality, individual’s sex, and trait-level agency. Although the intensity of self-induced pain may lessen, the defining qualities of pain cannot be erased. Learn more in #PAIN bit.ly/4eRvF3E
Baal et al. find that [18F]FTC-146 PET/MRI of sigma-1 receptor identified peripheral pain generators of complex regional pain syndrome, subsequently guided targeted treatments, and achieved varying degrees of improvements. Learn more in #PAIN bit.ly/4ud9JEK
Barnes et al. find that social and direct learning induced significant nocebo hyperalgesia, with distinct neurophysiological and autonomic patterns, highlighting the need to address expectancy-driven pain responses in clinical settings. Learn more in #PAIN bit.ly/4cHUxJV
Todd et al. find that pain-related mental imagery characteristics and psychological constructs predicted momentary and subsequent pain outcomes in young adults with chronic pain, identifying potential mechanisms and treatment targets #PAIN bit.ly/4cJpSvQ
Skin-to-skin contact for procedural pain may feel more daunting for parents of very preterm infants. Hashemi et al. find that increased support and education for families and clinicians could enhance its uptake and efficacy. Learn more in #PAIN bit.ly/42qXMj3
Cundiff-O’Sullivan et al. find that older brain age is associated with greater pain severity and pain interference, but placebo effects persist despite brain aging. Learn more in #PAIN bit.ly/4cGnJB0
Results from Edwards et al.’s crossover trial suggest that pharmacologic blockade of specific chemokine receptors was not effective in reducing moderate-to-severe pain from knee osteoarthritis. Learn more in #PAIN bit.ly/3QXCM0B
De Souza et al. find that CCL12 is upregulated after incision, directly sensitizes nociceptors, and its neutralization alleviates postoperative pain and prevents hyperalgesic priming, identifying a novel therapeutic target. Learn more in #PAIN bit.ly/4eUo849
Su et al. find that tonic pain shifts brain networks from functional segregation to integration, with a prominent role of the somato-motor network. Global network inferences effectively classify pain states. Learn more in #PAIN bit.ly/3OE4miS
In this week’s #PAIN Featured Image, Evans et al. depict a multidisciplinary framework for addressing pain and disability in leprosy, highlighting the need to address the broader health care needs of affected populations. Learn more at bit.ly/4uAo4M3
