Investigating kinase-dependent regulation of DNA replication and repair
Mathew Jones
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Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.
Pleased to see our latest research highlighted news.uq.edu.au/2025-10-ai-p...
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
For decades, human genome editing has been limited to small, localized modifications.
Today, in a new paper published in @science.org , researchers from Arc's Hsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
Happy to share our new review on 3D chromatin organisation by cohesin with you. It was a great pleasure to review recent advances and future prospects with @danielgerlich.bsky.social.
CAR T cells showcase the enormous potential of cell therapies, but often fail due to lack of evolutionary optimization. Today in @nature.com , we use #CELLFIE to engineer cell therapies at scale and share the largest resource of CRISPR screens in CAR T cells. www.nature.com/articles/s41...
Mathew Jones
Mathew Jones
🦘🧬Australian invited speaker list finalised for the
2025 Cell Cycle, DNA repair and Telomere Meeting!
Friday 5 Sep is your last chance to register at the EARLY BIRD rate & submit an abstract 🤩
australiancellcycle.org/australian-i...
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
Gerlich Lab
Arc Institute
Fena Ochs
Andrew Deans
Helfrid Hochegger
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
Researchers from the University of Queensland and University of Cambridge have developed a platform for human cells powered by artificial intelligence that could aid the development of therapeutics an...
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
Australian Cell Cycle, DNA repair and Telomere meeting draft schedule is now online!
Join us with 5 plenary speakers, 16 invited national speakers, 22 selected speakers, 61 poster presenters and lots and lots of fun science. Less than one month to go.
australiancellcycle.org/draft-schedu...
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…
We are in the process of inviting a number of outstanding Australian leaders in the fields of DNA repair, Cell Cycle and Telomere biology. Current invited speakers include: Lisa Alcock, Curtain Uni…
