Assoc. prof. at LUMC/@unileiden. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath Steering committee. Education officer ESGCD. Previously: @unigroningen and @mitofficial. https://sites.google.com/view/expbac-lumc/homepage
Wiep Klaas Smits (ExpBac/CMAT)
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Acidification-dependent suppression of C. difficile by pathogenic and commensal enterococci | Infection and Immunity journals.asm.org/doi/10.1128/... - #butcanitoccurinvivo, what do you think @joeyzacks.bsky.social ?
Interesting story: from FMT to LBP - 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial @natureportfolio.nature.com Nature Medicine www.nature.com/articles/s41...
Hosting @3cdf.bsky.social was a blast! Thanks to all attendees and presenters for sharing their exciting research! @robfagan.bsky.social @pssalgado.bsky.social @meeraunnikri.bsky.social @perbullough.bsky.social @johann-i2bc.bsky.social
Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...
Wiep Klaas Smits (ExpBac/CMAT)
Wiep Klaas Smits (ExpBac/CMAT)
Wiep Klaas Smits (ExpBac/CMAT)
Wiep Klaas Smits (ExpBac/CMAT)
The 3rd @3cdf.bsky.social is starting this time in Leiden with welcome from @smitslab.bsky.social
Hot off the press: insights into the role of the Y-complex in modulating RNA degradation in Bacillus subtilis
#SubtiWiki
www.nature.com/articles/s41...
Imagine you had six years of data and every year resistance levels go up ... What would you think will happen in the future?
(here showing data from quinolone resistance in E coli in Hungary from the supplement of this paper by @sonjalehtinen.bsky.social et al journals.plos.org/plospathogen...
Jörg Stülke
As part of @target-amr.bsky.social we have launched a comic, by the supremely talented Eddie Ross, called 'Genomic Detectives' in which we explain, for a broad audience, how genomics can help to counter drug-resistant infections.
You can read more about it here www.targetamr.org.uk/targetamr-la...
🛠️💉It's time for engineering contractile injection systems! @chipericson.bsky.social & @davidschaumann.bsky.social introduce programmable CIS - PROCIS, combining tail length control, non-native cargo loading, and cell retargeting all in one system! www.biorxiv.org/content/10.6... 🧵 1/5
High population diversity in the gut microbiota is generally correlated with health
across gastrointestinal diseases. Treatment with antibiotics can disrupt the gut microbiota
to the point that a sing...
After a lovely sunny lunch, we had Mia Urem from @smitslab.bsky.social with beautiful PolC structures! Now Fanny Denmay on erythromycin resistance @3cdf.bsky.social #3CdF2026
Prof Paula Salgado
A randomized, single-blind, parallel-group, phase 1b clinical trial compared fecal microbiota transplant or a 15-strain live biotherapeutic product (MTC01) derived from the same donor and found simila...
Author summary Bacteria use small signaling molecules to coordinate complex behaviors. In the filamentous soil bacterium Streptomyces venezuelae, the signaling molecule cyclic di-GMP controls the swit...
Transcriptional regulation is a central mechanism underlying bacterial adaptation to stress. Here, the authors used a genetic fitness screen to show that the Y-complex in Bacillus subtilis contributes...
