We also see a shift in CA1 recruitment during learning.
Neurons active before the threat, when the animal is simply exploring the context, are excluded from the engram.
This suggests that the hippocampus updates which neurons will store the memory as the experience unfolds.
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Gisella Vetere
Our preprint of my PhD’s work in @gisellavetere.bsky.social lab is finally out on BiorXiv: doi.org/10.1101/2024..., and I’m so excited to share it! If you’ve ever wondered about reconciling engram manipulation experiments and neuronal activity during encoding, you’re on the right thread! 1/14
How are associative memories formed? Which cells represent a memory, and when are they engaged? By visualizing and tagging cells based on their calcium influx with unparalleled temporal precision, we ...
