New online! Next-generation probiotics: an outlook into current applications and future developments
Nature Reviews Microbiology, Published online: 08 May 2026; doi:10.1038/s41579-026-01311-0In this Review, Kern, Tofield, Frame and Elinav discuss recent advances in the design of next-generation probiotics, from identification of candidates to therapeutic applications across diverse disease contexts, and highlight major challenges and the potential of artificial intelligence to develop effective, personalized probiotics with therapeutic functions.