I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
The CASP experiment is about to start - and is still short on challenging prediction targets. Ligand complexes, RNA, …
Structures of the QatBC complex from Angela Gao and Doug Wassarman in our group reveal an evolutionary link between QatABCD and Type IV CBASS and a role for protein deazguanylation in diverse anti-phage defense systems
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
ComEC structure is out!! 😍
Congratulations to the authors! That’s not an easy one. We have been trying for years to get that structure…
We failed and gave up.
Introducing Genie 3, a generative protein model that substantially advances the state-of-the-art for binder design, increasing in silico success rates by up to 20x on hard multimeric targets. It also debuts a form of inference-time scaling unobserved in other design models. 🧵1/8
Exciting times for our lab- recent developments in cryoET tools and workflows now allow us apply these to study microbes in the host context. #teamtomo
www.sciencedirect.com/science/arti...
I am so honoured to receive this prestigious distinction from #ISCB. 🥰
Thank you so much 🙏
Video
Chaque recherche en ligne, requête sur ChatGPT ou vidéo visionnée a un coût invisible : son empreinte environnementale 🌍💻 Pourtant, difficile de l’évaluer faute de normes et de données. Le projet Altimpact, porté par CNRS, ADEME et Inria, relève le défi.
#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social
one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes