“MyoD is not powerful because it commands other genes from above. It is powerful because its position in the regulatory network is such that its presence or absence reshapes the entire downstream landscape. Adding it to a fibroblast doesn’t just flip a switch; it reorganizes what the cell is." 💡
Nivedita Sarveswaran
@thetransmitter.bsky.social asked what scientific paper has impacted me most. Hal Weintraub's discovery that MyoD alone can convert naive cells into muscle cells seemed like magic. I've been chasing that kind of magic ever since: www.thetransmitter.org/this-paper-c...
A 1987 Cell paper inspired Ardem Patapoutian to think about the molecular codes that define neuronal subtypes.
