The journal for research and review articles in medicinal chemistry and related drug discovery science.
Published by @rsc.org 🌐 Website: rsc.li/rscmedchem
RSC Medicinal Chemistry
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📢 We are excited to announce this year’s Chemical Science symposium on the topic of digital chemistry in the age of AI and machine learning!
Find out more at rsc.li/chemscisymp2026
The symposium will be held in London, UK on the 29th and 30th of October 2026 in person only.
#ChemSciSymposium
Be sure to read research in our latest issue by Jeffrey W. Strovel, Steven Fletcher & co. @univofmaryland.bsky.social describing lead optimization of a quinolin-2(1H)-one-based inhibitor of the BRD4 member of BET protein family #medchem
Find their full report here👇
Don't miss this review from Fule Wu, Muneeb Ur Rehman, Sihui Long et al. at the Wuhan Institute of Technology in our latest issue providing a holistic view of the pharmacological landscape of carbolines #medchem
Check it out on our website🔽
🔓Check out this #OpenAccess paper in our latest issue by Zafer Asım Kaplancıklı & co. from Anadolu University reporting quinoline/thiazole compounds as selective acetylcholinesterase inhibitors #medchem
Read it in full below👇
Take a look at research by Adam McCluskey et al. in our latest issue investigating the clathrin inhibitory effects of substituted naphthoquinones #medchem
📍University of Newcastle, University of Queensland, @sydney.edu.au & @fmp-berlin.de
🔓Be sure to read this #OpenAccess review in our latest issue by Hakon Hakonarson & co. @childrensphila.bsky.social looking at the role of the thiol-based agent N-acetylcysteine in human health and disease #medchem
Find it in full here👇
📢Our latest issue is now online!
Check out the research behind the cover by Paul Harris, Margaret Brimble, Alan Cameron & co. @aucklanduni.bsky.social introducing CLipPA lipid chemodiversity to enzymatically truncated polymyxin B to combat Gram -ve pathogens #medchem
pubs.rsc.org/en/content/a...
🔓Don't miss this #OpenAccess review from Kagan Kerman & co. @chemuoft.bsky.social in our latest issue exploring the latest developments in modulators, antibody therapy and gene therapy targeting BACE1 #medchem
Check it out in full on our website🔽
pubs.rsc.org/en/content/a...
🔓Read #OpenAccess research by @smietana-m.bsky.social, @jeanyveswinum.bsky.social et al. @umontpellier.bsky.social in our latest issue harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases #medchem
Find it in full here🔽
Don't miss research in our latest issue by @wmwuest.bsky.social, Kevin P. C. Minbiole & co. @villanovapr.bsky.social & @emoryuniversity.bsky.social investigating octenidine and isooctenidine analogs as potential disinfectants #medchem
Check out the full article below👇
Chemical Science
The inhibition of the BET BRD4 protein has rapidly emerged as an indirect means of inhibiting the intrinsically disordered c-Myc proto-oncoprotein, a “holy grail” in oncology. Herein, we conducted…
Natural resources have served as a cornerstone for the discovery of innovative pharmaceutical compounds for millennia. Among the diverse natural compounds demonstrating significant pharmacological…
Acetylcholine (ACh), acetylcholinesterase enzyme (AChE), and AChE inhibition are of great importance in the treatment of neurodegenerative diseases. When it comes to AChE inhibition, FDA-approved…
N-Acetylcysteine (NAC) is the established antidote for acetaminophen toxicity and an approved mucolytic agent. Beyond these traditional uses, increasing evidence highlights its broader role as a…
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. A key feature of AD is the accumulation of amyloid beta (Aβ) peptides in the fo...
pubs.rsc.org
Bolinaquinone (BLQ, 1), a hydroxyquinone sesquiterpene, has been reported to inhibit clathrin mediated endocytosis. As there is no reported clathrin IC50 or commercial source of BLQ, we examined the…
This study presents the design and synthesis of a novel class of carbonic anhydrase inhibitors (CAIs) using oligonucleotides as an original multivalent platform. Single-stranded oligonucleotides…
Quaternary ammonium compounds (QACs) have been used in commercial disinfectants since the mid-1900s due to their strong antimicrobial activity and relatively low toxicity to eukaryotic cells.…
